Following an energy crisis, the world has become a desert wasteland and civilization has collapsed. Max Rockatansky, a survivor, is captured by the War Boys, the army of the tyrannical Immortan Joe, and taken to Joe's Citadel. Designated a universal blood donor, Max is imprisoned and used as a "blood bag" for a sick War Boy called Nux. Meanwhile, Imperator Furiosa, one of Joe's lieutenants, is sent in her armoured semi-truck, the "War Rig", to collect gasoline and ammunition. When she drives off-route, Joe realizes that his five wives—women selected for breeding—are missing, and are fleeing with her. Joe leads his entire army in pursuit of Furiosa, calling on the aid of nearby Gas Town and the Bullet Farm.
Nux joins the pursuit with Max strapped to his car to continue supplying blood. A battle ensues between the War Rig and Joe's forces. Furiosa drives into a sand storm, evading her pursuers, except Nux, who attempts to sacrifice himself to destroy the Rig. Max escapes and restrains Nux, but the car is destroyed. After the storm, Max finds Furiosa repairing the Rig, accompanied by the wives: Capable, Cheedo, Toast, the Dag, and the Splendid Angharad, who is heavily pregnant with Joe's child. Max steals the Rig, but Furiosa has activated a kill switch which disables it. Max reluctantly agrees to let Furiosa and the wives accompany him; Nux climbs on the Rig as it leaves and attempts to kill Furiosa, but is overcome and thrown out, and is picked up by Joe's army.
Furiosa drives through a biker gang-controlled canyon having bartered a deal for safe passage. However, with Joe's forces pursuing, the gang turns on her, forcing her and the group to flee, while the bikers detonate the canyon walls to block Joe. Max and Furiosa fight pursuing bikers as Joe's car, with Nux now on board, breaks through the blockade and eventually attacks the War Rig, allowing Nux to board and once again attempts to attack Furiosa, but fails and falls to the disappointment of Joe. However, as the Rig escapes, Angharad also falls off trying to help Max and is run over by Joe's car, killing her and her child. Furiosa explains to Max that they are escaping to the "Green Place", an idyllic land she remembers from her childhood. Capable finds Nux hiding in the Rig, distraught over his failure, and consoles him. That night, the Rig gets stuck in the mud. Furiosa and Max slow Joe's forces with mines, but Joe's ally, the Bullet Farmer, continues pursuing them. Nux helps Max free the Rig while Furiosa shoots and blinds the Bullet Farmer. Max walks into the dark to confront the Bullet Farmer and his men, wordlessly returning with guns and ammunition and covered in blood.
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