Resistance is a 2015 English-language Documentary History motion picture. 80 years ago antibiotics revolutionized medicine. Only now are we realizing the potentially catastrophic consequences of these miracle drugs.. The film is written and directed by Michael Graziano. Resistance was released on 15th March 2015. The Film was successful at box office. Resistance was made on a budget of $306 million and it was a super hit at box office gross of $2 billion.