Sulochana Dubey, nicknamed Sulu (Vidya Balan), is a middle-class housewife living in Virar with her family. Sulu enjoys her life to the fullest with her husband Ashok (Manav Kaul) and 11-year-old son. She dreams of being a working woman, but since she couldn't complete high school, she is unable to apply to white collar jobs. Her elder twin sisters mock her, seeing her as beneath them due to her education. Her husband, Ashok works as a manager in a tailoring firm: a frustrating job as everyone apart from him is unreasonable and over the age of sixty. On top of that, the firm is taken over by the owner's grandson, who is extremely rude. Her son is teased by a group of students who sell R-rated magazines and videos.
One day, Sulu wins a contest hosted by her favourite radio station and goes to the station to collect her prize. There, she sees a poster of auditions for an RJ, and feels that this is the job she is meant for. She meets the boss, Maria (Neha Dhupia), who finds her extrovert nature intriguing and gives her an opportunity to audition. Sulu laughs throughout the audition but at the end, says 'Hello' in a sensual tone, which impresses Maria. Maria asks if she would be able to do a call-in night show, where people would call her to talk about their problems and Sulu agrees.
Ashok is irritated at first that she took up the job without discussing with him but relents out of love for her. On her first day, Sulu faces an annoying caller who tries to change their chat into an obscene one. She is able to tactfully handle it. Next, she gets a request to sing, and excitedly does a song she only sings for her husband. Ashok is annoyed by all this, as well as frustrated with his new boss, who treats him terribly. Sulu's family are angry with her show and want her to quit but Ashok stands by her. The show becomes successful, making the radio station happy. Sulu also enjoys her work but Ashok continues taking out his frustration at home about both his job and hers. Sulu's life becomes high at work and low at home.
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