Not Safe with Nikki Glaser is a 2016 English-language Comedy series. Not Safe with Nikki Glaser is a free-form venue where comic and curious perv Nikki investigates sex and relationship topics through a mix of panel discussions, field pieces and social experiments. Not safe with nikki glaser stars Nikki Glaser in the title role along with an ensemble cast including Jake Taylor, Moshe Kasher, Bridget Everett, Kristen Schaal, Ron Funches and Jim Jefferies.